Tag: Psychedelics

Happy Bicycle Day!

Today might be Good Friday, but it’s also Bicycle Day – the celebration of the first deliberate acid trip.

On 19 April 1943, intrigued by ‘a peculiar presentiment’ and ‘excercising extreme caution’, chemist Albert Hofmann ingested 0.25 mg of lysergic acid diethylamide tartrate – ‘the smallest quantity that could be expected to produce some effect’. Or so he thought.

Hofmann recorded the details of his experiment in that day’s lab journal:

4/19/43
16:20: 0.5 cc of 1/2 promil aqueous solution of diethylamide tartrate orally = 0.25 mg tartrate. Taken diluted with about 10 cc water. Tasteless.
17:00: Beginning dizziness, feeling of anxiety, visual distortions, symptoms of paralysis, desire to laugh. Supplement of 4/21: Home by bicycle.

What followed was a remarkable descent into horror and beauty, confronting demons and angels, and finally an experience of death and rebirth. 0.25mg of LSD, it turned out, was a pretty big dose.

The next day, Hofmann writes:

A sensation of well-being and renewed life flowed through me. Breakfast tasted delicious and gave me extraordinary pleasure. When I later walked out into the garden, in which the sun shone now after a spring rain, everything glistened and sparkled in a fresh light. The world was as if newly created.

For more about the discovery of this remarkable compound, read Hofmann’s autobiography, LSD – My Problem Child, available online, for free. The story of his first self-experiment begins on page 11.

Happy Bicycle Day!

This is not the only Universe

In 17th century Europe, ‘a black swan’ was a by-word for an impossibility. But it took only a single observation of such swans in Australia to undo the presumption forever.

Today, Black Swan theory uses the metaphor to describe any argument or system of thought that can be undone at a single stroke

A psychedelic experience has the potential to be a Black Swan event for the individual.

Brain scans of individuals high on the drug revealed that the chemical allows parts of the cortex to become flooded with signals that are normally filtered out to prevent information overload.

Study shows how LSD interferes with brain’s signalling (The Guardian)

By ‘switching off’ the filtering mechanism of the thalamus, psychedelic compounds can, at a single stroke, help us overturn entire systems of thought that we once presumed not only true for us, but ‘real’ and inviolable.

This might explain the seemingly paradoxical subjective effects often reported in psychedelic-induced altered states of consciousness that are characterized by increased arousal as well as a dreamlike experience, impaired cognition but at the same time reported perceived mental clarity, and psychosis-like effects combined with blissful experiences.

Effective connectivity changes in LSD-induced altered states of consciousness in humans (PNAS)

As Aldous Huxley wrote after his experience with the psychedelic mescaline:

It’s a very salutary thing to realise that the rather dull universe in which most of us spend most of our time is not the only universe there is.

Moksha: Writings on Psychedelics & the Visionary Experience

Thanks to DRL for the inspiration for this little piece.

I believe in Psychedelics

1. Psychedelics on the NHS?

Last Friday I was at the Cube cinema in Bristol to watch a documentary about the first clinical trials involving classical psychedelics in decades.

In case you missed it, in 2016 Robin Carhart-Harris led a team at Imperial College London that trialled the psychedelic treatment of 20 depressed patients, 18 of whom had ‘severe, unipolar, treatment-resistant major depression’.

The trial gave promising results, with all 19 patients who completed the follow-up showing significantly reduced symptoms of depression for at least 5 weeks after the two psilocybin sessions.

18 of these patients did not seek any further treatment (medication or psychotherapy) for their depression until after the 5-week mark.

This is remarkable for a cohort that had, on average, a history of 4 previous failed medications.

Subtitled ‘Can Magic Mushrooms Cure Depression?’, it is to the credit of director Monty Wates that his film Magic Medicine is more about the illness than it is about the controversial compound that could hold the key to its treatment.

Indeed, I would argue that the only controversy is that it took Robin Carhart-Harris and his team more than 3 years just to secure government and ethics approval to use the psilocybin.

The Class A / Schedule 1 classification of psychedelics means that scientific research, and future medical treatment, is bureaucratically arduous and expensive.

Now that this therapy has been shown to be safe, it is time we reclassified psilocybin and let the scientific community spend their time and money where it belongs: on the treatment of disease.

The focus of Magic Medicine is quite rightly not on the profound psychedelic experiences of its participants, but on the shocking symptoms and consequences of living with depression.

Psilocybin offers hope to these people and we owe it to them to do what we can to realign the law with the science.

Four separate trials have reported improvements in depressive symptoms after psilocybin-assisted psychotherapy (Griffiths et al. 2016; Ross et al. 2016; Grob et al. 2011; Carhart-Harris et al. 2016), including one in which ‘treatment-resistant depression’ was the primary criterion for inclusion (Carhart-Harris et al. 2016).

Psilocybin has shown promise in the treatment of obsessive compulsive disorder (Moreno et al. 2006), alcohol (Bogenschutz et al. 2015) and tobacco addiction (Johnson et al. 2014) and anxiety related to terminal diagnoses (Griffiths et al. 2016; Ross et al. 2016; Grob et al. 2011).
[CITATION]

Unfortunately, of course, the treatment is currently illegal in the UK.

One thing we can all do is sign this government petition to reschedule psychedelics so that researchers like Robin Carhart-Harris can redouble their efforts to find treatments for the greatest mental health diseases of our age.

2. Psychedelics and Society

Along with most humans, I am captivated by experiences of awe, moments in which my self seems to dissolve into nature, where time and space have little relevance, and which seem to unveil to me the meaning of my puny existence.

Psychedelics are by no means the only route to such experiences – look out from a mountain top, have sex, ride a roller-coaster – but, once experienced, it would be foolish to argue that they are not one of the most direct.

Such a direct experience of awe is, I believe, the birth-right of all humans. Psychedelics change lives for the good, and not just those of people who have a diagnosable mental disease.

Psychedelic experiences are associated with measurable changes of personality in the direction of greater openness.

What does that mean?

In a pilot study, Taylor Lyons and Robin Carhart-Harris found that after two doses of psilocybin the participants’ measures of nature-relatedness were significantly increased, and that their political authoritarianism was significantly decreased. [CITATION]

Not only that, but these personality changes persisted 7-12 months after the psychedelic session.

For someone who would really rather like to live in a society that is more connected to nature and less politically authoritarian, this is a good news story.

3. Psychedelics and Mundane Wonder

Psychedelics can be used as a remarkable treatment for some of the most stubborn illnesses of the 21st century.

They can be used to explore the outer limits of consciousness, experience awe and transcendence, and perhaps change society for the better.

But they can also be used in the mundane, as an extraordinary part of ordinary daily life.

Microdosing is the way that I am very glad I was introduced to LSD. I am by nature cautious and was brought up in a drug-negative society that taught me to fear altered states of consciousness.

It doesn’t help that almost everything we think we know about psychedelics is wrong.

I can scarcely believe that I would have ever had the courage to take a large dose of a psychedelic had I not learnt the small way that these compounds would not – as I had been led to understand – send me insane.

But taking miniscule amounts of a psychedelic like LSD can have a surprisingly profound effect on your day.

In my experience, I find myself more open to social interaction with strangers, more appreciative of the beauty of the world, more able to focus on creative work, and more content with life.

In the words of pioneering researcher Jim Fadiman, more often than not microdosing helps people have ‘a really good day’.

Psychedelics for a Better Future?

In our hyper-rationalist culture, psychedelics are reminding us that there is another way of seeing the world.

Perhaps it’s just the re-emergence of a tradition that has been squashed in this country ever since the Romans banished the druids to Anglesey.

With the work of scientists like Robin Carhart-Harris at Imperial College London, psychedelics are showing us that transcendence can have a measurable and positive impact on our lives.

We have to be careful not to screw this up, but the time has come to support scientific psychedelic research, to support the right of individuals to explore their own consciousness through altered states, and to believe in the potential of psychedelics to change our future for the better.

Further Reading

  1. The Science of Psychedelics and Exceptional Human Experience (11 minute read) Start here for an introduction to everything I have learned about psychedelics over the last 2 years.
  2. A Really Good Day by Ayelet Waldman (16 minute read) My review of Ayelet Waldman’s book on microdosing LSD is, on the one hand, nothing more than a non-fiction book review. On the other, it is a fully-featured 3,000 word guide to psychedelic microdosing.

“No one ever died while breathing.” Psychedelic Breathwork with Alchemy of Breath

“No one ever died while breathing.” Anthony Abbagnano’s words are only somewhat comforting, as I settle down on my girlfriend’s yoga mat for an hour of hyperventilation.

Last night I spent the evening with about a hundred other yoga-matted breathers in the vast domed sanctuary of the Round Chapel in Clapton. The event was called Psychedelic Breathwork, and jointly organised by the excellent Psychedelic Society and Anthony’s organisation Alchemy of Breath. I had no idea what to expect – but at least now I could be optimistic that death would play no part in it.
Continue reading “No one ever died while breathing.” Psychedelic Breathwork with Alchemy of Breath

Counselling, Meditation and Psychedelics

Some of you probably know that, over the past 10 weeks, I’ve been studying person-centred counselling at the CityLit in London.

Some of you are perhaps also aware that I’ve recently (re)turned to mindfulness meditation to manage stress levels, as part of a concerted campaign against elevated Thyroid Peroxidase antibodies in my bloodstream.

And probably all of you know that over the last couple of years I’ve been investigating the transpersonal potential of psychedelics.

What I am slowly realising, however, is how tightly these three areas are woven together. Continue reading Counselling, Meditation and Psychedelics

The Science of Psychedelics and Exceptional Human Experience

“I don’t take reality for granted.”

Weird stuff happens. People really do experience telepathy, alien abduction and pre-cognition.

In the UK, we usually push such stories to one side and either forget about them, or (worse) medicate them. David Luke, Senior Lecturer for Psychology at the University of Greenwich tries to understand them. Continue reading The Science of Psychedelics and Exceptional Human Experience

A Really Good Day Psychedelic Microdosing with Ayelet Waldman

This article is ambidextrous. On the one hand, it is nothing more than a non-fiction book review. On the other, it is a fully-featured 3,000 word guide to psychedelic microdosing.

The book in question is A Really Good Day: How Microdosing Made a Mega Difference in My Mood, My Marriage and My Life by Ayelet Waldman. The title is a little coy – presumably so she can slip under society’s anti-drugs radar. Waldman is talking specifically about psychedelic microdosing, the habit of taking a very small dose of a psychedelic drug in the same way you’d take a microdose of caffeine with your morning coffee.

Waldman’s experiment lasted a month and follows the advice of Dr Jim Fadiman, who has been collecting informal reports from psychedelic microdosers for the last ten years or so. Once in every three days, Waldman would start her morning with a drop or two of diluted LSD, then continue her day as normal, recording observations on her mood, relationships and productivity at work. This book is her lab report.

Are you ready for this? So we begin, in conventional book review fashion. Continue reading A Really Good Day Psychedelic Microdosing with Ayelet Waldman

Are you experienced?

Imagine the scene. You’re on holiday with a big group of people you don’t know too well. The twelve of you hired a huge house in the countryside, sharing rooms to split the cost. You’ve been sunbathing on cushions in the garden, enjoying the sights, sounds and smells of summer, drifting away in a meditation on beauty.

At some point, somebody brought you a glass of water and a hummus, avocado, spinach and tomato sandwich on continental dark bread. You weren’t too hungry at the time, so only ate half the sandwich, leaving the remainder on the plate to dry in the hot sun. You drained the glass of water, grateful because you’d left your water bottle upstairs.

An hour or so later, you decide to return to the attic bedroom you share, for a lie down in the shade. As you poke your head through the attic trapdoor, you see the following, in series: a collection of cushions arranged around the sun-trap window overlooking the garden you’ve just left; a plate bearing a half finished hummus, avocado, spinach and tomato sandwich on continental dark bread; and a half full bottle of water – your bottle of water. You can’t help but be overtaken by the odd sensation that you’ve just entered a scene you only recently vacated: the same meditative garden view, the same sandwich, and your bottle of water. Continue reading Are you experienced?