Happy Bicycle Day!

Today might be Good Friday, but it’s also Bicycle Day – the celebration of the first deliberate acid trip.

On 19 April 1943, intrigued by ‘a peculiar presentiment’ and ‘excercising extreme caution’, chemist Albert Hofmann ingested 0.25 mg of lysergic acid diethylamide tartrate – ‘the smallest quantity that could be expected to produce some effect’. Or so he thought.

Hofmann recorded the details of his experiment in that day’s lab journal:

16:20: 0.5 cc of 1/2 promil aqueous solution of diethylamide tartrate orally = 0.25 mg tartrate. Taken diluted with about 10 cc water. Tasteless.
17:00: Beginning dizziness, feeling of anxiety, visual distortions, symptoms of paralysis, desire to laugh. Supplement of 4/21: Home by bicycle.

What followed was a remarkable descent into horror and beauty, confronting demons and angels, and finally an experience of death and rebirth. 0.25mg of LSD, it turned out, was a pretty big dose.

The next day, Hofmann writes:

A sensation of well-being and renewed life flowed through me. Breakfast tasted delicious and gave me extraordinary pleasure. When I later walked out into the garden, in which the sun shone now after a spring rain, everything glistened and sparkled in a fresh light. The world was as if newly created.

For more about the discovery of this remarkable compound, read Hofmann’s autobiography, LSD – My Problem Child, available online, for free. The story of his first self-experiment begins on page 11.

Happy Bicycle Day!

This is not the only Universe

In 17th century Europe, ‘a black swan’ was a by-word for an impossibility. But it took only a single observation of such swans in Australia to undo the presumption forever.

Today, Black Swan theory uses the metaphor to describe any argument or system of thought that can be undone at a single stroke

A psychedelic experience has the potential to be a Black Swan event for the individual.

Brain scans of individuals high on the drug revealed that the chemical allows parts of the cortex to become flooded with signals that are normally filtered out to prevent information overload.

Study shows how LSD interferes with brain’s signalling (The Guardian)

By ‘switching off’ the filtering mechanism of the thalamus, psychedelic compounds can, at a single stroke, help us overturn entire systems of thought that we once presumed not only true for us, but ‘real’ and inviolable.

This might explain the seemingly paradoxical subjective effects often reported in psychedelic-induced altered states of consciousness that are characterized by increased arousal as well as a dreamlike experience, impaired cognition but at the same time reported perceived mental clarity, and psychosis-like effects combined with blissful experiences.

Effective connectivity changes in LSD-induced altered states of consciousness in humans (PNAS)

As Aldous Huxley wrote after his experience with the psychedelic mescaline:

It’s a very salutary thing to realise that the rather dull universe in which most of us spend most of our time is not the only universe there is.

Moksha: Writings on Psychedelics & the Visionary Experience

Thanks to DRL for the inspiration for this little piece.